染色体外にDNA発見 genannetics:

Small DNA circles discovered outside the chromosomes in mammalian cells and tissues, including human cells
DNA is usually coiled tightly into chromosomes.  These newly discovered microDNA circles are NOT attached to chromosomes, but are created when segments of DNA are excised from the coding and control regions in somatic cells, creating micro-deletions, possibly leading to disease.

The researchers theorize that future work in this area could lead to new knowledge about the causes of autism or schizophrenia, which may be due to incorrect functioning of certain genes in brain tissue.


Microdeletions in protective genes, such as tumour suppressors, could render them inactive and thus reduce protections against cancer, so this discovery is relevant to cancer research.

New discoveries in basic science mechanisms like this are fascinating, informing lots of different fields of biology!  Way cool!

染色体外にDNA発見 genannetics:

Small DNA circles discovered outside the chromosomes in mammalian cells and tissues, including human cells

DNA is usually coiled tightly into chromosomes.  These newly discovered microDNA circles are NOT attached to chromosomes, but are created when segments of DNA are excised from the coding and control regions in somatic cells, creating micro-deletions, possibly leading to disease.

The researchers theorize that future work in this area could lead to new knowledge about the causes of autism or schizophrenia, which may be due to incorrect functioning of certain genes in brain tissue.



Microdeletions in protective genes, such as tumour suppressors, could render them inactive and thus reduce protections against cancer, so this discovery is relevant to cancer research.

New discoveries in basic science mechanisms like this are fascinating, informing lots of different fields of biology!  Way cool!

アストロサイト(緑) medicalschool:

A false-color view of human brain tissue shows an astrocyte (green) reaching out to a blood vessel (yellow and red). The neurons (blue) are not in direct contact with the vessel and rely on astrocytes for the transport of nutrients or waste.

アストロサイト(緑) medicalschool:

A false-color view of human brain tissue shows an astrocyte (green) reaching out to a blood vessel (yellow and red). The neurons (blue) are not in direct contact with the vessel and rely on astrocytes for the transport of nutrients or waste.

コウジ酸 micro-scopic:

Hydroxymethyl Pyrone Crystallites
Also known as kojic acid, hydroxymethyl pyrone is widely used in the medical field as a pain killer, and an anti-inflammatory drug. It has dermatologic applications, used as a protective agent against UV light, and to lighten pigment spots and discolorations on the skin by inhibiting the formation of pigment. In the food industry, this antioxidant is also used as a precursor of flavor enhancers and to inhibit discoloration in agricultural products (by inhibiting polyphenol oxidase).

コウジ酸 micro-scopic:

Hydroxymethyl Pyrone Crystallites

Also known as kojic acid, hydroxymethyl pyrone is widely used in the medical field as a pain killer, and an anti-inflammatory drug. It has dermatologic applications, used as a protective agent against UV light, and to lighten pigment spots and discolorations on the skin by inhibiting the formation of pigment. In the food industry, this antioxidant is also used as a precursor of flavor enhancers and to inhibit discoloration in agricultural products (by inhibiting polyphenol oxidase).

fuckyeahmolecularbiology:

Staphylococcus aureus (pictured in red), the bacterial cause of MRSA (short for Methicillin-Resistant Staphylococcus aureus).

fuckyeahmolecularbiology:

Staphylococcus aureus (pictured in red), the bacterial cause of MRSA (short for Methicillin-Resistant Staphylococcus aureus).

thefrogman:

[original images]

アメリカでも桜吹雪

Cat’s eye

Cat’s eye

earth-song:

by mehmet karaca

earth-song:

by mehmet karaca

2004年8月に買って、昨年末まで会社で個人使用(WIn PC)していました。手前のパッドがややくたびれ感があり、本体から外れやすくなっていますが、接着剤やテープなどでの補修はしていません。好みで外してパッド無しでも使えるかと思います。それ以外は機能的にも全く問題ありません。自宅では別の白モデルをMacで使っています。

fckyeaharthistory:

Giuseppe Arcimboldo - Rudolf II (Holy Roman Emperor) painted as Vertumnus, Roman God of the seasons, 1590-1. Oil on canvas 

fckyeaharthistory:

Giuseppe ArcimboldoRudolf II (Holy Roman Emperor) painted as Vertumnus, Roman God of the seasons, 1590-1. Oil on canvas 

bobbyaguilera:

Manhattan circa 1910. “Singer Building down Broadway from the post office.” - Detroit Publishing Company. View full size.

bobbyaguilera:

Manhattan circa 1910. “Singer Building down Broadway from the post office.” - Detroit Publishing Company. View full size.

夙川は桜の名所ですが、川下付近に群生している純白のユキヤナギも見事でした。平日ながら川沿いは賑わっていました。

夙川は桜の名所ですが、川下付近に群生している純白のユキヤナギも見事でした。平日ながら川沿いは賑わっていました。

左は袋のみで、右がイースターエッグ入り。

左は袋のみで、右がイースターエッグ入り。

funnywildlife:

Pretty Frog!!!

funnywildlife:

Pretty Frog!!!

allthingseurope:

Kilchurn Castle, Scotland (by kenny barker)

allthingseurope:

Kilchurn Castle, Scotland (by kenny barker)